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The Role Of Sodium Carboxymethyl Cellulose CMC In The Pharmaceutical Industry

Sodium Carboxymethyl Cellulose CMC is anionic cellulose ether, the appearance of white or yellowish flocculent fiber powder or white powder, odorless and tasteless, non-toxic; soluble in cold water or hot water to form a certain viscosity Of the transparent solution. The solution is neutral or slightly alkaline, insoluble in ethanol, ether, isopropyl alcohol, acetone and other organic solvents, soluble in water containing 60% ethanol or acetone solution. There is hygroscopicity, the light and heat stability, viscosity decreases with increasing temperature, the solution in the PH value of 2 to 10 stable, PH less than 2, a solid precipitation, PH value is higher than 10 viscosity decreased. Discoloration temperature 227 ℃, carbonization temperature 252 ℃, 2% aqueous solution surface tension 71mn / n.

Sodium Carboxymethyl Cellulose CMC In the pharmaceutical industry can be used as injections of emulsion stabilizer, tablet binder and film-forming agent. Some people through the basic and animal experiments show that CMC is safe and reliable anti-cancer drug carrier. Using CMC as the membrane material, the development of Chinese medicine Yangyin sorex powder modified dosage form - Yangyin sarcoma, can be used for skin grinding wound and traumatic wound. Animal model studies have shown that the film prevents wound infection, and no significant difference with the gauze dressing, in the control of wound tissue fluid exudation and wound healing, the film was better than gauze dressing, and reduce the postoperative edema and wound stimulation. With the polyvinyl alcohol: Sodium Carboxymethyl Cellulose CMC: polycarboxylate 3: 6: 1 ratio of the film made of the best prescription, adhesion and release rate are increased in the mucosal adhesive sustained-release film The adhesion of the agent to extend the retention time in the oral cavity and the efficacy of the drug in the preparation are significantly improved. Bupivacaine is a potent topical anesthetic, but it can sometimes produce more severe cardiovascular side effects when poisoning, so the clinical application of bupivacaine in clinical practice, its toxicity research has been more attention. Pharmacy studies have shown that CIVIC formulated as a sustained-release substance with a picocaine solution significantly reduces the side effects of the drug. In the PRK operation, the use of low concentrations of caine and non-steroidal anti-inflammatory drugs combined with CMC can significantly relieve postoperative pain. Prevention of abdominal surgery after peritoneal adhesions, reduce the occurrence of intestinal obstruction is one of the most concerned about clinical surgery. Studies have shown that CMC to reduce the degree of postoperative peritoneal adhesions was significantly better than sodium hyaluronate, can be used as an effective way to prevent the occurrence of peritoneal adhesions. CMC for the treatment of liver cancer ductal hepatic artery infusion of anti-cancer drugs, can significantly extend the anticancer drug in the tumor retention time, enhance the anti-tumor force, improve the therapeutic effect. In animal medicine, CMC also has a wide range of uses. It has been reported that [5] pointed out that the infusion of 1% CMC solution into the abdomen of the ewes to prevent livestock dystocia, reproductive tract surgery after abdominal adhesions have a significant effect.

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