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Sodium Carboxymethyl Cellulose (CMC)

Sodium carboxymethyl cellulose (CMC)

The cellulose derivative is prepared by treating cellulose with sodium hydroxide to form alkali cellulose, and then reacted with chloroacetic acid. The glucose unit that makes up cellulose has 3 hydroxyl groups which can be replaced, so that products with different degrees of substitution can be obtained. The average dry weight of each 1g was transferred into 1mmol carboxymethyl group, which was insoluble in water and dilute acid, but could be used for ion exchange chromatography. Carboxymethyl pKa in pure water is about 4, about in 0.5mol/L NaCl, is a weak acidic cation exchanger, usually more than pH4 for the separation of neutral and basic proteins. More than 40% of the carboxyl group is soluble in water to form stable high viscosity colloid solution.

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